A top 5 Pharmaceutical Company is hiring in their Boston-based DMPK group, requiring a professional and skilled DMPK scientist to join their team. This company has over 40 commercialized drug products spanning many therapeutic areas and many continents! They have a strong commitment to diversity and inclusion as well as excellent benefits and packages.If you are interested in joining a driven and passionate team who values a flexible working environment and improving the lives of patients, read more below.What would you be doing? Lead a skilled DMPK/ADME team in driving studies in the support of the preclinical portfolio.Develop ADME hypotheses and studies.Employ knowledge of PK/PD and TK to develop studies to evaluate drug delivery, DDI, and optimization strategy to inform strategic decisions.Work cross-functionally with interdisciplinary teams such as biology, medicinal chemistry, clinical pharmacology, therapeutic area project groups as well as global teams.Collaborate on regulatory submissions on ADME specific parameters and collaborate with regulatory agencies. Requirements: PhD in Pharmacokinetics, Biochemistry, Cell Biology or a related field.7+ years in the pharmaceutical industry in preclinical drug discovery.Experience with biological-therapeutics.Experience with PK/PD modeling, data analysis, and bioanalytical method and assay development.Experience collaborating with regulatory agencies and writing regulatory documents (IND, NDA, BLA).Self-starter mentality, confidence working independently.  

SciPro has partnered with a small molecule, stealth biotech backed by a top-tier Venture Capital firm, offering a highly collaborative and entrepreneurial environment. Focused on targeting cholesterol homeostasis, we are advancing multiple CNS therapeutic programs and scaling towards NDA filings.They are seeking an experienced Head of Clinical Pharmacology & DMPK to lead and own their Clinical Pharmacology function across all phases of development (IND, Phase I-III, and NDA filings). This role reports directly to the Chief Scientific Officer and offers the opportunity to make a significant impact on our programs as we prepare for Phase 2 Proof-of-Concept studies and NDA submissions. Key Responsibilities: Lead and own the Clinical Pharmacology function for NDA submission and oversee all related Nonclinical activities.Develop in vitro and in vivo ADME screening and DMPK study plans for early research programs.Support dosing decisions and interpret data using PK software.Collaborate with and oversee external parties for modeling work and data interpretation.Partner with the CSO and leadership team to drive development and execution of clinical studies.Contribute to the growth and scaling of a rapidly evolving biotech, bringing hands-on expertise and leadership.  Qualifications: PhD and 8+ years of experience in the pharmaceutical indsutry.Extensive experience in Clinical Pharmacology & DMPK, with a proven track record of supporting IND through NDA stages.Expertise in in vitro and in vivo ADME screening, DMPK study plans, and dosing strategies.Proficient in PK software and data interpretation.Experience collaborating with external partners for modeling and related activities.A self-starter and "builder" mindset, with the ability to adapt and thrive in a fast-paced biotech environment.  What They Offer: The chance to work with a highly successful and visionary C-Suite leadership team.A stable financial backing, with ongoing funding rounds to support clinical advancements.The opportunity to shape the future of CNS therapies in a mission-driven, innovative organization.

An emerging Immuno-Therapy Biotech out of Boston is hiring for a VP/Head, DMPK. This company is focused on developing therapeutics in the immune-therapy space (oncology, inflammation). They are focused on Preclinical R&D and looking to continue development in the coming 6 months, requiring leadership for their growing DMPK team.You will be providing oversight and input into overseeing and designing early preclinical and nonclinical in vivo studies. You will be the touchpoint for various therapeutic area staff and responsible for translating PKPD analysis. You will support Pharmacokinetic (PK) and Pharmacodynamic (PD) requirements for discovery and IND-stage project teams by approving summary reports and documents supporting regulatory findings.You will oversee a team of multiple scientists, hiring for additional members, as well as play a major strategic part in the day-to-day development of the company. You will have the ability to join the company and take part in its fast-paced, efficient novel therapeutic discovery.What would you be doing? Contribute on and provide leadership to discovery-stage project teams as a subject matter expert for the preclinical group, providing PK and PK/PD input to the design of preclinical studiesFoster and drive a culture of high quality experimental design, data generation and analysis to support decision making on individual programsProvide cross-functional leadership to champion the use of novel approaches for drug discovery and developmentDrive productive and collegial partnerships across clinical, translational and research teamsIdentify and manage consultants and vendors to support DMPK studiesEffectively communicate functional area matters to stakeholders internally and externallyWork cross functionally with Therapeutic Area stuff and groups like Biology, Chemistry, Clinical Development & Operations, Regulatory etc.Ensure compliant operation of activities including clinical pharmacology trials and GLP laboratory activities. Additionally, be responsible for management of the departmental budgetsMaintain updated knowledge of scientific literature as well as regulatory guidance and standards as they pertain to PK/PD  Requirements: Minimum PhD in Pharmacology, Pharmacokinetics, Biology/Molecular Biology, or Biochemistry10-12 years relevant industry experience (Biotech or Pharma)In-depth understanding DMPK and be able to describe pharmacology/ biology of therapeutic proteinsExperience overseeing DMPK studies across different stages of drug discoveryExperience leading a team, had previously had 3-4 direct reportsExcellent communication and presentation skillsPrevious experience in the following therapeutic areas – oncology, inflammation/immunologyExperience with small molecules